Clinical Advisory
Clinical Use Advisory: Post Facial Fat-Loss Treatments
Who this is for: Clients who have undergone or are considering treatments like Kybella®, RF microneedling, ultrasound skin tightening, laser contouring, or any heat-based or fat-reducing facial procedure.
When to Use Caution
Please consult your provider before use if you’ve had any of the following:
- Kybella® or deoxycholic acid treatments
- Radiofrequency skin tightening or RF microneedling
- Ultrasound-based lifting (e.g., Ultherapy)
- Laser fat contouring or thermal-based facials
PowerV™ supports the environment surrounding hypodermal fat cells and may promote a gentle, localized cushioning effect over time. If you’re in the middle of an active fat-loss treatment plan, PowerV™ may not align with your goals.
When To Consider PowerV
Facial volume represents youth.
Facial fat isn’t something to fear, it’s essential. It cushions the skin, keeps the face lifted, and maintains long-term structural harmony. That’s why many clients eventually seek dermal fillers: to restore the youthful volume lost over time.
However, some tightening procedures (especially heat-based ones) can unintentionally affect subcutaneous fat, particularly when overused or improperly applied. These treatments may cause minor trauma to fat cells in the hypodermis, leading to long-term volume depletion that isn’t immediately visible.
PowerV™(Key Ingredient PhytoCellTec™ Argan from Mibelle BioChemistry) was inspired for & by clients who want to tighten , but also supporting the system that preserves what makes their face look naturally youthful. It supports skin barrier, antioxidant protection, and supports the deeper natural regenerative processes linked to facial volume.
When PowerV™ May Be Ideal
If you’ve experienced volume loss or want to protect your facial fat post-procedure, PowerV™ may be a strong fit. Especially for clients who:
- Are concerned about over-thinned cheeks or under-eyes
- Regret past fat-loss treatments
- Want to maintain their skin’s structural bounce after tightening procedures
Scientific Support: How Fat and Stem Cells Work in Skin
Q: Don’t fat cells stay the same after adulthood?
Yes, in your body (abdomen, thighs, etc.), fat cell count stays mostly stable. They shrink or expand based on weight.
BUT… your facial skin has a small, local pool of stem cells in the hypodermis designed to replace lost fat cells gradually, and that process slows with age.
Q: Is losing body fat the same as losing facial volume?
NO, these are two very different biological processes.
When you lose weight intentionally (through diet and exercise), your body burns stored fat for energy. The fat cells shrink in size, but their total number stays the same, this is a healthy, systemic process.
Facial volume loss, on the other hand, is often driven by localized cell depletion, especially in the skin's hypodermis. This can happen due to aging (when stem cell activity declines), or after certain aesthetic procedures (when trauma disrupts the fat-supportive environment). In these cases, you’re not just shrinking fat, you’re losing the cells themselves, along with their ability to regenerate.
So while weight loss affects fat distribution in the body, facial volume loss is about structural decline, a completely different issue that requires regenerative skin support, not fat burning.
You can be a healthy weight and still experience hollowing in the cheeks or under-eyes due to the natural decline in regenerative fat cells in the skin.
Unlike healthy weight loss, where fat cells shrink but the overall number remains stable, age-related volume loss involves an actual reduction in the number and vitality of fat cells in the face.
On the other hand, If you're planning to lose weight, it's important to do so with a gradual, well-supported plan that gives your skin time to adapt. Rapid weight loss can leave the skin without the fat cushion it needs to appear full, smooth, and lifted, especially in the face. Slower, more balanced weight loss allows skin to tighten and recover while maintaining its structural integrity.
PowerV™ is formulated to support that specific regenerative mechanism, not by shrinking fat cells systemically, as occurs in weight loss, but by supporting the visible integrity of skin structure through the natural, age-regulated activity of hypodermal stem cells. This process helps maintain the skin’s natural volume and resilience in areas where regenerative fat support is needed.
Q: Is it important to support your skin’s natural fat volume, especially in the face?
Yes, facial fat volume plays a major role in how youthful, lifted, and resilient your skin appears. As we age, the fat cushion beneath the skin naturally thins due to a decline in stem cell activity, structural breakdown, and certain aesthetic treatments. Supporting the skin’s ability to maintain its natural fat-supportive environment can help preserve facial harmony, reduce visible hollowing, and delay the need for more invasive interventions like fillers. PowerV™ is uniquely formulated to nourish this environment, offering subtle support for long-term volume and skin structure.
1. Your Skin Has Hypodermal Stem Cells
In your deepest skin layer (hypodermis), you have adipose-derived stem cells (ADSCs). These:
- Support your facial fat cushion
- Help maintain fullness and bounce
- Decline in number and function with age
2. These Stem Cells Can Become Fat Cells When Needed
Stem cells are blank slates. In skin, they can become:
- Fibroblasts (for collagen)
- Keratinocytes (for the epidermis)
- Adipocytes (fat cells) to maintain volume
This happens only when the body signals it’s needed, it’s localized, regulated, and subtle.
3. What PowerV™ Does
PowerV™ features PhytoCellTec™ Argan, a patented plant stem cell technology that:
- Supports in tightening hypodermal-dermal junction (VIVO CLINICAL STUDY)
4. Localized Action Only
PowerV™ only works where it’s applied, and only in the skin. It does not enter your bloodstream or affect body fat stores.
Myth vs. Truth
| Myth | Truth |
|---|---|
| "Fat cells never change." | True for the body, but in skin, stem cells can become fat cells when needed. |
| "Skincare makes you gain fat." | False. PowerV™ supports the skin’s natural regenerative environment to help maintain visible structure, it does not increase fat or body weight. |
| "Stem cell skincare = uncontrolled fat growth." | False. Your body controls what converts, and only as needed. |
Summary
Key Ingredient PhytoCellTec™ Argan in PowerV™ supports the skin’s structural foundation by supporting the visible integrity of skin structure through localized, age-regulated activity in the dermal-hypodermal junction. For clients concerned about facial visible volume, resilience, and post-procedure support, PowerV™ offers a gentle, appearance-focused, and science-informed solution.
For clinical partners: If you’d like a version of this advisory for your front desk team or esthetician protocols, please contact us.
Collapsible content
YOU ARE BEAUTIFUL
Skincare can feel overwhelming—you're constantly being pulled in different directions, told what to use, what to avoid, and who to listen to. But let us be clear: you are already beautiful, just as you are.
At PowerV™, we see you. We hear your frustration. And we’re here not to fix you—but to support you. Skincare shouldn't make you feel less than. It should feel like a return to yourself. Our mission is to meet you where you are and walk alongside you with intention, compassion, and science.
IMPORTANT - When should I NOT USE PowerV™?
PowerV™ is NOT recommended for individuals who are currently undergoing or planning active fat-reduction treatments such as Kybella®, radiofrequency, or ultrasound-based facial contouring. If your goal is to continue reducing volume, using PowerV™ during this time may not align with your intended results.
However, if you are UNHAPPY with the outcome of a fat-reduction procedure and wish to support your remaining facial structure and volume, PowerV™ may be appropriate. It’s designed to maintain the skin’s natural environment and appearance - help preserve visual harmony and resilience over time.
Additionally, avoid using PowerV™ if you have a known sensitivity to any of its ingredients.
From our Founder. What made you start PowerV? Why now?
Honestly, I think I was just overwhelmed. There were so many options out there, so many routines, so many promises, but nothing was truly giving me what I was looking for.
I wasn’t chasing a miracle product. What I wanted was something that could genuinely support the skin long-term, not just create a temporary effect. Something that didn’t sit on the surface but was developed with a deeper understanding of how the skin maintains its strength, balance, and natural vitality over time. And I couldn’t find that. So I decided to create it.
I wasn’t trying to outdo anyone. I just wanted to build something honest, effective, and rooted in real science, not marketing. This isn’t just another serum. It’s skincare designed to support the visible health of your skin at every level:
Support for the skin’s natural fullness and density with patented plant stem-cell technologies studied for their role in helping skin look smoother and more resilient over time.*
Antioxidant protection from one of the strongest natural antioxidants known, to help the skin defend against environmental stressors that contribute to visible signs of aging.*
A triple-barrier hydration system that helps the skin feel deeply moisturized, calm, and comfortable.
Ingredient science focused on long-term skin balance and vitality, because true care starts with understanding how the skin renews itself.*
But beyond the science, there’s something deeper that inspired me to create this.
So much skincare today comes at a cost, harsh actives, unnecessary irritation, and ingredients that don’t always align with skin harmony. And when people turn to more aggressive options, there’s often little conversation about the long-term effects on the skin’s comfort, balance, or appearance.
It’s heartbreaking, honestly.
Because people, especially women, are constantly being sold quick fixes and unrealistic promises. That’s exactly what we’re against.
At PowerV, we believe in transparency over fear. In understanding over pressure. And in giving your skin what it truly needs, not just now, but for years to come.
My hope is that PowerV helps women make more informed, confident choices about their skin. Because with consistent use, this serum helps the skin look smoother, more balanced, and visibly stronger, naturally.
*Based on studies of individual active ingredients, not the finished product
What makes PowerV different from other skincare brands?
We couldn’t find a formula that supported anti-aging from every angle and still respected the skin, so we built it ourselves. PowerV supports anti-aging from all angles, hydration, firmness, antioxidant protection, and barrier support, using clinically backed ingredients in one formula. No trends, no toxicity, just deep skin science.
Is Skincare Alone Enough to Prevent Aging?
Skincare is powerful, but it’s only one part of the equation.
At PowerV, we believe in supporting your skin from all angles: topically with intelligent, science-backed ingredients, and internally through the choices you make every day. If you're investing in skincare, it only makes sense to support it with healthy habits that reinforce those results, not work against them.
That means prioritizing anti-inflammatory foods, berries and fruits rich in antioxidants, lean proteins to support collagen, and regular movement to improve circulation and cellular repair. Because let’s be honest, if you’re spending on advanced skincare, but eating in ways that cause inflammation and stress, you’re undoing the very results you're trying to achieve.
Healthier eating habits and regular exercise are just as important as what you apply on your face. When combined with PowerV, you’re not just caring for your skin—you’re supporting your body, your mind, and your long-term well-being.
Is it really clean beauty?
Yes. No endocrine disruptors, no parabens, no synthetic fragrance. Every ingredient is safe, effective, and chosen with purpose.
What does Astaxanthin do?
Astaxanthin, one of the most powerful antioxidants, with 6,000 times the oxidative stress-fighting strength of Vitamin C (*). It's known for its ability to help protect the skin from environmental stressors and visible signs of aging.
Why Beta-Glucan instead of Hyaluronic Acid?
Beta-Glucan is a powerful ingredient known for its ability to deeply hydrate and support the skin barrier. It helps calm and repair sensitive skin, providing long-lasting moisture retention. While Hyaluronic Acid is also a great hydrator, Beta-Glucan offers enhanced soothing and barrier-strengthening benefits, making it ideal for skin that is prone to irritation or sensitivity.
Do you really use stem cells?
Yes, patented, biotech-developed plant stem cells, not just plant extracts. They're studied for improving firmness and skin density over time.
Is it for sensitive skin?
Yes The New Skincare by PowerV is Dermatology Tested on Sensitive Skin. It’s made without harsh actives to support skin health without irritation, thanks to barrier-strengthening ingredients like ceramides, squalane, and beta-glucan.
When will I see results?
Many users notice improvements with continued use. Clinical studies on our core ingredients show that with consistent use, skin elasticity, hydration, and firmness typically improve within 4-8 weeks.
Does PowerV help with skin sagging or volume loss?
As we age, the supportive fat layer beneath the skin naturally begins to thin, leading to visible sagging, hollowness, and a loss of firmness over time. PowerV is formulated to support the skin barrier, boost hydration, and strengthen elasticity, which helps maintain the look of plump, resilient skin.
By nourishing the skin’s foundation and reinforcing its structure with ingredients like Beta-Glucan, Ceramides, and Squalane, PowerV helps preserve the healthy environment surrounding these fat cells, supporting long-term skin volume and bounce.
That’s why we advocate for prevention, not just correction. Supporting your skin early helps protect its structure, slow visible signs of aging, and keep your skin strong, balanced, and radiant over time.
What makes Astaxanthin so powerful for aging skin?
Imagine your skin is a busy city, and your cells are the workers. Now picture a storm of free radicals (unstable molecules caused by sun, pollution, and stress) constantly trying to damage the buildings (your collagen and elastin).
Astaxanthin acts like a microscopic bodyguard, standing between the chaos and your collagen. It neutralizes those free radicals before they can break things down, helping prevent wrinkling, dullness, and sagging.
Under the microscope: Astaxanthin is absorbed into the lipid layer of your skin cells, where it sits at the membrane and protects cell structures from oxidative stress. This keeps skin cells functioning longer and prevents inflammation that leads to aging.
How does Beta-Glucan hydrate and heal skin from within?
Beta-Glucan (Moisture Magnet + Cell Communicator)
Inside the deeper layers of your skin, there are cells that regulate repair, hydration, and immunity. These cells communicate like neighbors, but when your skin is stressed, the lines get fuzzy.
Beta-Glucan works like a messenger and water reservoir. It attaches to receptors on immune cells and helps regulate inflammation, while simultaneously pulling moisture deep into the skin.
Microscopically: Beta-Glucan molecules penetrate the epidermis and form a gel-like matrix between skin cells, trapping water while signaling cells to reduce inflammation and improve repair. This leads to smoother, healthier skin from within.
What do Ceramides and Squalane actually do for my skin barrier?
They are Your Lipid Wall Builders.
Your skin barrier is made of lipids (fats) that form a protective wall, like the bricks and mortar of a building. With age, that wall gets cracks (dryness, irritation, sensitivity).
Ceramides fill in the “mortar,” while Squalane acts like a flexible, skin-identical oil that seals it all together, without clogging pores.
Microscopically: These lipids physically integrate into the outermost layer of skin cells (stratum corneum), strengthening the skin’s structure and preventing water loss. A healthy barrier also reduces exposure to pollution and bacteria, which can accelerate aging.
Can skincare really help prevent sagging and volume loss?
Beneath the skin is a thin layer of fat (adipose tissue). With age, this layer thins out—leading to hollowing, sagging, and a loss of bounce.
While topical skincare generally don't replace fat, ingredients like Beta-Glucan, Ceramides, and antioxidants help preserve the environment around fat cells—keeping them healthier, hydrated, and less inflamed.
In your skin: When the tissue around fat cells is nourished and inflammation is reduced, volume is better preserved. The skin stays visibly fuller, more lifted, and youthful-looking for longer."
Is it important to support your skin’s natural fat volume—especially in the face?
Yes—facial fat volume plays a major role in how youthful, lifted, and resilient your skin appears. As we age, the fat cushion beneath the skin naturally thins due to a decline in stem cell activity, structural breakdown, and certain aesthetic treatments. Supporting the skin’s ability to maintain its natural fat-supportive environment can help preserve facial harmony, reduce visible hollowing, and delay the need for more invasive interventions like fillers. PowerV™ is uniquely formulated to nourish this environment, offering subtle support for long-term volume and skin structure.
Don’t fat cells stay the same after adulthood?
Yes—in your body (abdomen, thighs, etc.), fat cell count stays mostly stable. They shrink or expand based on weight.
BUT… your facial skin has a small, local pool of stem cells in the hypodermis designed to replace lost fat cells gradually—and that process slows with age.
Is losing body fat the same as losing facial volume?
NO, these are two very different biological processes.
When you lose weight intentionally (through diet and exercise), your body burns stored fat for energy. The fat cells shrink in size, but their total number stays the same, this is a healthy, systemic process.
Facial volume loss, on the other hand, is often driven by localized cell depletion, especially in the skin's hypodermis. This can happen due to aging (when stem cell activity declines), or after certain aesthetic procedures (when trauma disrupts the fat-supportive environment). In these cases, you’re not just shrinking fat, you’re losing the cells themselves, along with their ability to regenerate.
So while weight loss affects fat distribution in the body, facial volume loss is about structural decline, a completely different issue that requires regenerative skin support, not fat burning.
You can be a healthy weight and still experience hollowing in the cheeks or under-eyes due to the natural decline in regenerative fat cells in the skin.
Unlike healthy weight loss, where fat cells shrink but the overall number remains stable, age-related volume loss involves an actual reduction in the number and vitality of fat cells in the face.
On the other hand, If you're planning to lose weight, it's important to do so with a gradual, well-supported plan that gives your skin time to adapt. Rapid weight loss can leave the skin without the fat cushion it needs to appear full, smooth, and lifted, especially in the face. Slower, more balanced weight loss allows skin to tighten and recover while maintaining its structural integrity.
What are hypodermal stem cells, and where are they found?
In your deepest skin layer (called the hypodermis), your body stores adipose-derived stem cells (ADSCs). These special cells:
- Help maintain your facial fat cushion
- Contribute to volume, bounce, and youthful appearance
- Naturally decline in both number and vitality as you age
Can these stem cells become fat cells?
Yes. Stem cells are like blank slates. Under the right signals, they can become:
- Fibroblasts (collagen-producing)
- Keratinocytes (for skin surface renewal)
- Adipocytes (fat cells) that help maintain facial volume
This is a natural, subtle process regulated by your body. It doesn’t happen unless the skin needs to replenish lost fat.
Myth 1 - "Fat cells never change."
True for body fat, but in face & OR skin, stem cells can become fat cells when needed to maintain volume.
Should I use PowerV™ to help prevent or delay the need for FACIAL FILLER?
PowerV™ is not a substitute for injectable fillers, but it may help extend the time before you feel the need for them. Fillers work by instantly replacing lost volume beneath the skin. PowerV™, on the other hand, supports the skin's natural environment over time by helping maintain the environment that protects visible volume and skin resilience.
By supporting the skin’s natural environment, PowerV™ may help your face maintain a more visible lifted, balanced appearance as you age. For clients looking for a non-invasive way to support long-term volume and delay early signs of structural loss, PowerV™ offers a gentle, science-backed approach.
Should I use PowerV™ if I’ve undergone a facial fat-loss treatment?
NO - PowerV™ is not recommended for use during or after facial fat-reducing treatments, especially if your goal is to continue reducing facial volume.
However, if you're unhappy with the amount of volume lost, PowerV™ may be a supportive option.
